Лекарственные вещества, классифицированные по их химическому составу и основному активному компоненту.


205 публикаций

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Translational Animal Models in Colitis: From Rodents to Pig and Minipig Platforms
Mechanistic Exploration of Half-Sandwich Iridium(III) Anticancer Compounds through Integrated Cellular, Proteomic, and In Vivo Analyses
6-gingerol attenuates renal interstitial fibrosis by downregulating PI3K/Akt/mTOR signaling pathway in unilateral ureteral obstruction rats
Development and validation of HPLC-FLD method for simultaneous determination of ternary therapy used for COVID-19 in plasma samples
Contemporary Type 2 Diabetes Guidelines: Converging Evidence, Diverging Strategies, and the Position of the Korean Diabetes Association Framework
Comparative nutritional and anti-nutritional composition of Aframomum melegueta leaves and seeds
The Potential of Using Smell and Smellscapes at Nursing Homes to Support the Well-Being of People with Dementia
Comprehensive analysis of minoxidil effectiveness for hair growth
Photodynamic therapy enhances dacarbazine sensitivity of melanoma cells by induction of apoptosis and downregulation of PI3K/AKT signaling pathway
Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells
The Noradrenergic Brain in Parkinson’s Disease
Mood stabilizers and systemic inflammatory burden in euthymic patients with bipolar disorder: a comparative study of lithium and valproate
THE REPUBLIC OF TRANSLATIONAL MEDICINE
A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock
Successful Use of Octreotide in Refractory Intradialytic Hypotension: A Case Report
Central and peripheral glutamatergic biomarkers delineate heterogeneous clinical phenotypes in olanzapine-treated schizophrenia
Embodied transitions: Cultural framings of menopause among minority ethnic women
Unveiling anti-atherosclerotic targets of Perilla frutescens through a multi-scale computational framework integrating network pharmacology, single-cell analysis, machine learning, and molecular dynamics
Araticum (Annona crassiflora) seed extract as a chemopreventive agent against prostate cancer: activation of extrinsic and intrinsic apoptotic pathways in a preclinical model
Developing WNT-derived bone anabolic peptides for skeletal aging and fracture by reconstructing thumb and index domains of WNT7B
Drug-induced gastric motility disorders: A disproportionality analysis from the FAERS and CVARD databases
A DPHV–liver module recapitulates AML infiltration and chemotherapy-induced hepatotoxicity with translational utility
Synthesis and In Vitro Evaluation of a Novel Tyrosinase-Targeting Cyclic Peptide with Radical Scavenging Activity
Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration
Development and characterization of ivermectin nanoformulations for topical acaricidal activity against Rhipicephalus sanguineus ticks
Paroxetine HCl-Loaded Polymeric Nanoparticles for Colorectal Cancer Therapy: Optimization by Box–Behnken Design and Evaluation of Antiproliferative Efficiency on HCT-116 Cells
Computational stratification and engineering framework of the PDCD1/CD2 immune axis in triple-negative breast cancer
The occurrence of pharmacologically active dyes in the aquatic environment as a result of water and wastewater contamination—an underestimated environmental problem
Quercetin Delivered by Mesenchymal Stem Cell-Derived Exosomes Improves Liver Fibrosis via the PI3K/Akt Signaling Pathway
Exploring the bioactive potential of green synthesized silver nanoparticles coated serratiopeptidase and chalcone derivatives
Finerenone attenuates myocardial injury and enhances vascular repair via regulation of autophagy, apoptosis, and angiogenesis
Efficacy and safety of once-weekly basal insulin analogs versus daily basal insulin analogs in adults with type 2 diabetes: a systematic review and meta-analysis
AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation
Recent research progress of plant-derived chlorogenic acid in cancer therapy: Anticancer mechanism and combination therapy
Pharmacokinetics, bactericidal activity and toxicity of short oral regimens for rifampicin-resistant tuberculosis treatment
Advances in the management of pediatric short bowel syndrome: mechanisms of intestinal adaptation and emerging role of GLP-2-based therapies
IMPACT OF PEGYLATION ON BIOPHARMACEUTICS: MECHANISMS, APPLICATIONS, AND FUTURE PERSPECTIVES – A REVIEW ARTICLE
Statin-Associated Muscle Symptoms and Myotoxicity: A Clinically Oriented Narrative Review with a Practical Prevention, Evaluation, and Management Algorithm
A COMPLETE REVIEW ON ADVANCEMENTS IN TRANSDERMAL PATCH TECHNOLOGY FOR PAIN MANAGEMENT AND HORMONE DELIVERY
The Anticonvulsant Effect of Long-Term Valproate Might Be Attributable to Altered Expression of Selected Genes in Mice
Structural diversity and chemical space analysis of a PROTAC database using unsupervised machine learning
IMPACT OF PEGYLATION ON BIOPHARMACEUTICS: MECHANISMS, APPLICATIONS, AND FUTURE PERSPECTIVES – A REVIEW ARTICLE
IN SILICO MOLECULAR DOCKING ANALYSIS AND ADME PROFILING OF THE SIDDHA HERBAL FORMULATION GOWTHAMAR CHOORANAM AGAINST CHRONIC BRONCHITIS
Target trial emulation: A practical framework for credible real-world evidence of healthcare interventions
GPCR Biased Signaling: Conceptual Advancements and Therapeutic Innovation
СПЕТРОФОТОМЕТРИЧЕСКИЙ МЕТОД КОНТРОЛЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ
Novelties in the pragmatic management of anaphylaxis in pediatric age
Mesoporous silica nanoparticle-mediated delivery of a synergistic 5-miRNA combination inhibits HSV-2 infection
Pharmacological Management of Peptic Ulcer Bleeding
Management of Peptic Ulcer Disease in Patients Taking Antithrombotic Agents
FURAN-BASED CHALCONES DERIVATIVES: SYNTHESIS, ANTIOXIDANT EVALUATION, DFT CALCULATIONS AND ADME PREDICTIONS
Multitarget Actions of Pentacyclic Triterpenic Acids in Alzheimer’s Disease: Mechanistic Insights
Essential oils from Salvia marashica and Salvia multicaulis as natural ingredients: phytochemical composition, antioxidant activity, enzyme inhibition, and molecular docking studies
Intranasal theophylline as an adjunct to corticosteroid therapy in post-COVID-19 anosmia: a randomized clinical trial
In vitro antitumor efficacy of hyaluronic acid coating for curcumin-loaded zeolitic imidazole frameworks-8 (ZIF-8) versus that of uncoated curcumin-loaded ZIF-8 nanocomposites
Dose–Response and Clinical Equivalence of Semaglutide and Tirzepatide for Weight Loss in Type 2 Diabetes: A Model-Based Analysis
Screening of putative inhibitors for cytotoxin VacA from Helicobacter pylori
How Drug–Drug Interaction Studies Inform Drug Labeling: A Survey of US Food and Drug Administration‐Approved New Molecular Entities from 1998 to 2022
Updating CMV protocols in lung transplant patients: a single-center case study modeling use of generative AI for antimicrobial stewardship protocol development and economic impact analysis
Phytochemicals from natural sources classification physiological roles and health benefits
Prognostic, diagnostic and therapeutic value of the cancer tubulin code
Anisodine hydrobromide targets matk and prevents delayed rtPA thrombolysis-induced vasogenic cerebral edema in ischemic stroke
Molecular mechanism of Tian-Wang-Bu-Xin-Dan in the treatment of Alzheimer’s disease: A network pharmacology and molecular docking study
Рекомендации по разработке определений использования лекарств с акцентом на реальные источники клинических данных
Переход к регулированию обращения лекарственных средств по правилам ЕАЭС: финальный период
Требования к материалам раздела по стандартным образцам, представляемым в досье на биологические лекарственные средства
Comparative Effectiveness of Olmesartan Medoxomil in Monotherapy and Combination Therapy With Other ARB Medications: Literature Review
Metabotropic signaling downstream of GABAA receptors suppresses neuroinflammation in Parkinson’s disease
Cost-utility of long-term exercise therapy in people with axial spondyloarthritis and severe functional limitations: a randomized, controlled trial
Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors
Volume kinetics of intravenous crystalloid and colloid solutions in healthy, isoflurane-anesthetized rabbits
Molecular and structural insights into carvacrol and thymol alkylated derivatives targeting WSSV and AHPND-causing Vibrio parahaemolyticus
Antimicrobial synergism of silver and zinc oxide nanoparticles with antibiotics against clinical isolate of Cutibacterium acnes
Targeting of Leishmania proteins by β-Lapachone derivatives reveals a promising multitarget candidate
One-pot click synthesis of hybrid triazole–pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays
Curcumin versus placebo in benign prostatic hyperplasia: a systematic review and meta-analysis
Levofloxacin/ketorolac combination versus levofloxacin alone for topically treating moderate-severe acute bacterial conjunctivitis: a randomized controlled trial
An update on recent developments in the drug treatment of tuberculous meningitis
Psychosocial factors that are predictive of changes in pain severity in the multidisciplinary treatment of chronic pain: A cohort study
Natural product-inspired mitotic poisons in cancer pharmacotherapy
Update on the Management of ABCA4 Retinopathy (Stargardt Disease)
Adenosine Dose and Cardioversion in Pediatric Supraventricular Tachycardia: A Systematic Review and Meta-Analysis
Prader-Willi Syndrome:New treatment perspectives and insights
Pharmacological Effects of the Main Active Components in Curcumae Rhizoma: A Review
Effect of respiratory acid-base balance on rocuronium-induced neuromuscular blockade and sugammadex-induced reversal in rat phrenic nerve hemidiaphragm
Hepatoprotective Potential of Dactyloctenium aegyptium (L.) Willd. (Egyptian Crowfoot Grass): A Systematic Literature Review
Beyond Urease: New Potential Enzymatic Targets in <i>Helicobacter pylori</i>
A Scalable Stereoselective Synthesis of Polysubstituted Housanes
AYURVEDIC MANAGEMENT OF SICKLE CELL ANEMIA: A COMPREHENSIVE REVIEW
Mapping metabolic reprogramming in lung and breast cancer through integrative bioinformatics
Efficacy of ketoconazole ear wash versus conventional topical antifungal therapy in otomycosis: a prospective randomized controlled trial
Comparison of acute effects of 3,4-methylenedioxymethamphetamine (MDMA) with and without a supplemental booster dose in healthy participants: a double-blind, randomized, placebo-controlled, crossover study
Incidence of Skin Infections in Patients with Atopic Dermatitis Treated with Topical Medications: A Cohort Study Using Japanese Claims Data
AYURVEDIC MANAGEMENT OF SICKLE CELL ANEMIA: A COMPREHENSIVE REVIEW
Tigecycline Enhances Sensitivity to FOLFIRINOX and Gemcitabine/Nab-Paclitaxel in Pancreatic Ductal Adenocarcinoma In Vitro Models
Paeoniflorin in rheumatoid arthritis: Translational insights and limited clinical evidence
Design synthesis and evaluation of a novel 1,3,4-thiadiazole derivative as a potent anticancer and antibacterial agent supported by electronic property analysis and simulation studies
IN SILICO MOLECULAR DOCKING ANALYSIS AND ADME PROFILING OF THE SIDDHA HERBAL FORMULATION- SATHURMUGA CHOORNAM AGAINST PALMOPLANTAR PSORIASIS
IN SILICO MOLECULAR DOCKING ANALYSIS AND ADME PROFILING OF THE SIDDHA HERBAL FORMULATION- SATHURMUGA CHOORNAM AGAINST PALMOPLANTAR PSORIASIS
In silico characterization of bioactive phytochemicals as antivirals targeting the reovirus σ1 protein for inhibiting σ1-mediated host cell entry
Gelsenicine as an emerging foodborne hazard: phytochemistry, pharmacokinetics, and mechanistic toxicology in a systems framework
A Review on Antileismanial Activities of Thiazol Derivatives
Crossing the Septum: May-Thurner Syndrome and Patent Foramen Ovale as a Dual Mechanism for Recurrent Ischemic Stroke
Research progress and challenges in in vivo CAR-T cell therapy
A REVIEW OF FORMULATION AND EVALUATION OF ANTI FUNGAL CREAM USING DIFFERENT PLANT EXTRACT
Eco-friendly green synthesis of zinc oxide nanoparticles using Acalypha indica L. leaf extract and their incorporation into topical formulations for acne and skin infection treatment
DIABETOLOGY IN MODERN PHARMACY: AN UPDATED AND CONCISE REVIEW
A REVIEW OF MOLECULAR DOCKING INVESTIGATIONS ON IMIDAZOLE DERIVATIVES FOR ANALGESIC ACTIVITY
Promising Anti‐Cancer Effects and Mechanisms of Baicalin and Baicalein in the Treatment of Oral Cancer: A Comprehensive Review
Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder
Effects of fluoroquinolone antibiotics on extracellular matrix-related phenotypes in tendon cells
Distinctive features of the tumor and immune microenvironment in glioblastoma
Liposomal Nanoparticle-Based Drug Delivery System for Enhanced Bioavailability in Anticancer Therapy: A Comprehensive Review
Liposomal Nanoparticle-Based Drug Delivery System for Enhanced Bioavailability in Anticancer Therapy: A Comprehensive Review
DIABETOLOGY IN MODERN PHARMACY: AN UPDATED AND CONCISE REVIEW
MORPHIN - A SYSTEMATIC REVIEW
A REVIEW OF FORMULATION AND EVALUATION OF ANTI FUNGAL CREAM USING DIFFERENT PLANT EXTRACT
A REVIEW OF MOLECULAR DOCKING INVESTIGATIONS ON IMIDAZOLE DERIVATIVES FOR ANALGESIC ACTIVITY
Antibody–drug conjugates in colorectal cancer: molecular design, preclinical advances, and translational challenges
AndroMETa-Lung-713: A phase 2/3 study of telisotuzumab adizutecan (ABBV-400, Temab-A) vs standard of care (SOC) in patients with epidermal growth factor receptor ( <i>EGFR</i> )–mutated non–small cell lung cancer (NSCLC).
Combating small extracellular vesicle–mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides
Targeting epigenetic and DNA topology mechanisms: histone deacetylases and topoisomerase inhibitors in combination and dual inhibition approaches
Structural basis of Fumosorinone-mediated allosteric inhibition of PTP1B for cancer immunotherapy
Development of novel anti-cancer drug by “locking inhibition” of amino acid transporter LAT1.
Evaluation of the safety profile of glucagon-like peptide-1 receptor agonists: a focus on thyroid cancer-related adverse events by using the European pharmacovigilance database
First-in-human clinical evaluation of ST-01156, an optimized and selective degrader of RNA-binding motif 39 (RBM39): A phase 1 study in advanced solid malignancies with a focus on RBM39-dependent cancers.
Integrative In Vivo and Transcriptomics‐Guided In Silico Profiling of <scp> <i>Citrus sinensis</i> </scp> Phytochemicals as Multi‐Target Anticoccidial Agents
Dihydrosanguinarine: A Review of Its Pharmacology, Structure–Activity Relationship, Toxicity, Pharmacokinetics, and Clinical Prospects
SARM1 inhibition to prevent chemotherapy-induced peripheral neuropathy: Translational and early clinical evaluation of SIR2501.
Towards generalizable seizure monitoring: EpiVLM for cross-environment detection and classification
Mineralocorticoid receptor antagonists for the treatment of heart failure and kidney disease: a state-of-the-art review
Thymoquinone protects against statin-induced cerebellar damage, apoptosis, and hepatic cytotoxicity in rats
Research advances in the application of betulinic acid for anti-inflammatory and anti-tumour therapy
Pharmacokinetics, Mass Balance, and Metabolism of [ <sup>14</sup> C]TPN729, a Selective and Potent Phosphodiesterase Type 5 Inhibitor in Humans
Population Pharmacokinetics and Pharmacodynamics of Immunoglobulins: A Systematic Review
Antibody–drug conjugates in cancer therapy: do we need biomarkers? A comprehensive review
Synergistic antiproliferative and pro-apoptotic effects of postbiotics and chemotherapy in human lymphoma cells: mechanistic insights from proteomics and oxidative stress pathways
Comparison of Outcomes From Sequential Endoscopic Therapy in 60 Patients With Cirrhosis and Esophagogastric Varices Treated at a Provincial and a Tertiary District Hospital
Phytochemical signatures and multifunctional bioactivities of two Ocimum basilicum varieties (Obb vs. Obg): antimicrobial, antioxidant, and anticancer potential
Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles
Psilocybin modulates social behaviour in male and female mice in a time-dependent manner
Synthesis, in-vitro and in-silico bioactivity and computational studies of pyrene and p-methoxycinnamaldehyde linked 4-hydroxycoumarins
Standardizing antiviral response metrics for mono- and combination therapies in acute, chronic and latent viral infections
Impact of clinical pharmacist interventions on drug-related problems in hospitalised patients with renal dysfunction: a quasi-experimental study
A highly sensitive LC-MS/MS method for the determination and quantification of four mutagenic nitrosamine impurities in bempedoic acid drug substance
Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus and Liver Cirrhosis: A Systematic Review and Meta-Analysis
Computational design, synthesis and biological evaluation of novel pyridinone derivatives as NNRTIs
Breaking Barriers Between Species: Integrated Multi‐Species <scp>PK</scp> Models Improve Human <scp>PK</scp> Predictions
In Vitro Analysis and Dynamic Modeling of SARS-CoV-2 Infection Inhibition by Sigma-1 Receptor Antagonist PB28
The Sensitive Nose: Allergic and Non-allergic Causes
A kidney-protective mechanism via cellular oxidative stress reduction induced by CD5L protein
Moral Neuroenhancement and the Discernibility Challenge
Fractionated testosterone gel replacement therapy in clinical practice: A real-world exploratory clinical experience
Effects of transcutaneous electrical nerve stimulation in postoperative total knee arthroplasty pain and intravenous analgesic requirement
Black mulberry (Morus nigra L.) fruits: A miracle from nature for human health
Pharmacological intervention for renal ischemia-reperfusion injury with dose-matched glucocorticoids
The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects
In silico evaluation of Glycyrrhiza glabra phytochemicals as potential inhibitors of SARS-CoV-2 main protease (3CLpro)
Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond
Safety profile of aromatase inhibitors combined with CDK4/6 inhibitors: a real-world analysis based on FAERS
Drug-drug interactions with direct oral anticoagulants in Belgian primary care patients with non-valvular atrial fibrillation
Burden of Intrapancreatic Fat Deposition in Type 2 Diabetes and the Role of Obesity: A Systematic Review and Meta-Analysis
Trends in EU regulatory assessment of oncology medicines
Compensatory nephron hypertrophy: mechanisms, pathophysiology dynamics, and clinical implications in acute kidney injury and chronic kidney disease
Specificity of non-motor symptoms of Parkinson’s disease : A systematic review and meta-analysis
<i>In silico</i> profiling of date palm pollen phytochemicals: Molecular interactions with sperm-associated proteins and implications for male fertility
Pharmacological principles of intravitreal drug therapy and their implications for clinical practice: a primer for the ophthalmologist
Anisodus tanguticus in Cancer Research: A Review of Traditional Use, Phytochemistry, Extraction Methods, and Preclinical Antitumor Evidence
Recent Developments in the Drug Treatment of Parkinson’s Disease
O-GlcNAcylation reprograms microglial inflammatory states and attenuates Alzheimer’s disease pathology
Adjunctive D-cycloserine to intermittent theta-burst transcranial magnetic stimulation in fibromyalgia: a randomized placebo-controlled trial
Agri-Food By-Products as Sources of Bioactive Compounds: Nutritional Value, Health Effects, and Functional Food Applications
PHYTOTHERAPY IN PHTHISIOLOGY: ANALYSIS OF ADJUNCTIVE APPROACHES DURING STANDARD ANTI-TUBERCULOSIS TREATMENT
Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossover, fully controlled feeding trial
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Therapeutic potential of alpha-tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol-induced seizures
Building bridges in migraine management: consensus pathways on best practices across primary and specialist care in Italy
TCM-Derived Natural Compounds Targeting the Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease: Gut–Liver Axis Mechanisms, Safety Considerations, and Translational Challenges
In vitro and in vivo investigation of potent platinum(IV) prodrugs for clinical anticancer therapy
Green TLC-densitometric method for determination of cytarabine and granisetron in spiked human plasma: optimization and whiteness assessment
Dose-Dependent Effects of Atropine on Accommodative and Binocular Visual Function for Myopia Control in Children: A Systematic Review and Meta-Analysis
Comprehensive scientific insights on plant inspired nano therapeutics as the missing piece of the breast cancer puzzle
Resveratrol as a potential natural compound to ameliorate cognitive impairment in aluminum-exposed mice: impacts on behavior, purinergic system, and brain inflammation
Intrathecal hydromorphone for postoperative pain management in gastrectomy: a dose-finding and randomized controlled study
Evolving landscape of potassium-competitive acid blockers: toward disease-specific use beyond acid suppression
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
Pharmacokinetic and Tolerability Comparison Between Over-the-Counter and Prescription Azelastine Hydrochloride Nasal Spray for Allergic Rhinitis Management
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults
Edoxaban for atrial fibrillation in patients with atherosclerotic disease in daily clinical practice
Heparin-incorporated whey protein isolate-derived hydrogels with an intended dual function as snakebite wound dressings and drug delivery systems inhibit spitting cobra venom-induced cytotoxicity
BACE1 Inhibitors: Design, Synthesis, Structure–Activity Relationships, and Therapeutic Applications in Alzheimer’s Disease and Beyond – An Updated Review
Intracardiac vs. Transesophageal echocardiography in left atrial appendage occlusion: real-world comparative effectiveness from a propensity-matched cohort
Minimal Systemic Exposure with Maximal Delgocitinib Cream Use in Patients with Severe Chronic Hand Eczema in the DELTA 2 Randomized, Vehicle-Controlled, Double-Blind, Phase 3 Trial
Optimized ultrasound neurostimulation of ventromedial prefrontal cortex reverses depression behaviours and normalizes brain metabolism
Bridging the Gap in Chronic Prurigo Care: Evidence-Based Diagnostic and Therapeutic Recommendations from a Delphi Consensus Panel
Phytosomes against melanoma: disrupting molecular pathways with targeted phytochemical delivery
Flavonoid-enriched fractions of Pimpinella anisum and Coriandrum sativum: antioxidant, hepatoprotective, and antimutagenic activities supported by in vivo and dynamics simulation studies
Nutraceutical Properties of Oyster Mushrooms (Pleurotus spp.): A Comprehensive Review with Special Reference to Indian Varieties
Decoding the Snail transcriptional network: its role in cancer progression and therapy
Diagnosis and Classification of Diabetes Mellitus
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration